What to Expect During Your First Ketamine Infusion Session
June 28, 2025

What to Expect During Your First Ketamine Infusion Session

Starting a new treatment can be overwhelming—but at Sage Health & Wellness, we're here to guide you every step of the way. If you’re considering ketamine infusion therapy, understanding what happens during your first session can help ease anxiety and give you the confidence to take that first step.

Ketamine therapy has been shown to offer relief for individuals dealing with treatment-resistant depression, anxiety, PTSD, and chronic pain. Let’s walk through what you can expect when you come in for your first infusion.

Before Your Appointment: Initial Consultation

Your journey begins with a detailed consultation with one of our experienced providers. This visit includes a full review of your medical history, a discussion of your symptoms, and a chance to explore whether ketamine therapy is a safe and appropriate option for you.

At Sage, we prioritize safety and personalization. If you’re a good candidate, we’ll work with you to create a treatment plan tailored specifically to your needs.

Preparing for Your Infusion

Ahead of your appointment:

  • Eat a light meal about 4 hours before your session.

  • Avoid alcohol, caffeine, nicotine and recreational substances.

  • Dress comfortably.

  • Arrange for someone to drive you home after treatment.

These small steps can help make your session more comfortable and effective.

What Happens During the Infusion

When you arrive at Sage Health & Wellness, you’ll be welcomed into a calm, private infusion room designed to help you feel relaxed and safe. After a quick review of your vitals and treatment plan, a small IV will be placed in your arm or hand.

The infusion itself usually lasts around 40–60 minutes. During that time, many patients experience:

  • A feeling of lightness or detachment

  • Visual or sensory changes

  • Deep relaxation or introspection

You’ll be monitored throughout the entire session by trained medical staff to ensure your safety and comfort. Some patients listen to calming music or bring an eye mask to enhance their relaxation.

Immediately After the Infusion

After the infusion is complete, we’ll give you time to rest and recover. Most people feel a bit groggy, calm, or mentally reflective. You’ll be observed until you’re ready to leave with your companion.

Our team will provide clear aftercare instructions and help you plan your next steps.

Frequently Asked Questions

Is ketamine safe?
Yes, when administered in a clinical setting by trained professionals, ketamine is safe and well-tolerated. At Sage, your safety is our top priority.

Will I feel “high” or lose control?
Most patients feel relaxed or mildly dissociated but remain aware of their surroundings. The effects are temporary and monitored closely.

How many sessions will I need?
Treatment plans are individualized. A typical protocol starts with a series of 6 infusions over 2–3 weeks. Many patients experience significant relief after a few sessions.

How soon will I feel better?
Some patients notice improvement after the first infusion, while others may need a few sessions. The full benefit often unfolds over time.

Why Choose Sage Health & Wellness?

At Sage, we don’t just administer ketamine—we create a therapeutic experience. Our team is compassionate, experienced, and dedicated to providing you with the safest, most comfortable care possible. Every aspect of our clinic, from the calm environment to personalized treatment plans, is designed with your well-being in mind.

If you're curious about ketamine therapy, we invite you to book a consultation. We’re here to answer your questions and help you decide if this treatment is right for you.

– Written by Natalie Centeno Registered Nurse (RN)

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