If you or someone you love has been struggling with depression, chances are you’ve explored traditional antidepressants like SSRIs or SNRIs. But what happens when those medications don’t provide relief? At Sage Health & Wellness, we offer ketamine therapy as an innovative and promising alternative for individuals with treatment-resistant depression, anxiety, PTSD, and chronic pain.
So, how does ketamine differ from traditional antidepressants—and why are more patients considering this option? Let’s break it down.
How Traditional Antidepressants Work
Most antidepressants, such as SSRIs (Selective Serotonin Reuptake Inhibitors) and SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors), work by increasing the availability of certain neurotransmitters in the brain—mainly serotonin and norepinephrine. These chemicals play a role in mood regulation, and adjusting their levels can help improve symptoms of depression over time.
However, traditional antidepressants often:
- Take 4–6 weeks to begin working
- May require trying multiple medications to find the right fit
- Can cause side effects like weight gain, sexual dysfunction, and emotional blunting
- Don’t work effectively for up to one-third of patients
How Ketamine Works Differently
Ketamine takes a completely different approach. It targets the brain’s glutamate system, which plays a key role in mood regulation and neuroplasticity (the brain's ability to form new connections). Ketamine is thought to "reset" parts of the brain affected by depression, providing fast and sometimes dramatic relief.
What makes ketamine unique:
- Works within hours or days, not weeks
- Can be effective for treatment-resistant depression
- Promotes the growth of new neural pathways
- May also help with anxiety, PTSD, and chronic pain
Frequently Asked Questions
Is ketamine safe?
Yes—when administered by trained professionals in a clinical setting like Sage Health & Wellness, ketamine is safe and well-tolerated. We closely monitor every session to ensure your comfort and security.
How is it administered?
At Sage, we offer ketamine via intravenous (IV) infusion, which is the most researched and effective method for mental health treatment.
Will I need ongoing treatment?
Most patients begin with a series of infusions (typically 6 over 2–3 weeks), followed by periodic booster treatments as needed.
Can I continue my current antidepressants?
In many cases, yes. Ketamine can be used alongside other medications, but your provider will evaluate your current treatment plan to ensure safety.
Why Choose Sage Health & Wellness?
At Sage, we don’t just provide ketamine therapy—we deliver care designed around your whole wellness journey. Our team takes the time to listen, personalize your treatment plan, and support you from your first consultation to every follow-up. Our serene treatment rooms and professional oversight create a safe, nurturing space for healing.
If you’ve tried traditional antidepressants without success, ketamine may be a life-changing alternative. We’re here to help you find hope again.
– Written by Tin Le, Integration Coach, Medical Assistant (MA)
