Structured Treatments

Multiple sessions of Ketamine Infusion Therapy offer enhanced and sustained benefits across a range of conditions. For individuals struggling with treatment-resistant depression, anxiety, and PTSD, a series of infusions helps rewire neural pathways, leading to more durable symptom relief and emotional stability. Patients with chronic pain conditions such as fibromyalgia or CRPS often require multiple sessions to effectively reduce pain intensity and improve mobility. Regular treatments support neuroplasticity, reduce relapse rates, and improve overall quality of life, making multi-session protocols an essential part of achieving long-term therapeutic outcomes.

TABLE OF CONTENTS

Why Multiple Sessions Are Recommended

1. Cumulative Neurological Impact

2. Building Long-Term Relief

3. Condition-Specific Protocols

Benefits of Regular Sessions

Recommended Maintenance Schedule

Reference List

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At Sage, we advocate for a structured approach to Ketamine Infusion Therapy. Clinical research and patient outcomes consistently show that a series of infusions provides significantly better, longer-lasting results than a single treatment. Here’s why:

Ketamine works by promoting neuroplasticity—helping the brain form new, healthier neural connections. This process is reinforced with each session, leading to a more substantial and sustained improvement in mood and function.

While some patients may feel initial relief after the first infusion, long-term improvements typically emerge after a course of 6 infusions over 2 to 3 weeks. This schedule allows for stabilization of symptoms and prevents regression.

• Depression, Anxiety, PTSD: Usually benefit from 6 initial sessions followed by periodic boosters (monthly or as needed).
  
• Chronic Pain (e.g., CRPS, fibromyalgia): May require longer infusions or a higher number of sessions for sustained relief.
  
• Bipolar Depression or Treatment-Resistant Depression: Often see improved outcomes with customized multi-session protocols.
  

• Lasting Mood Stabilization
  Maintenance sessions help prevent relapse, especially in treatment-resistant conditions.
  
• Improved Daily Function
  Patients often report enhanced focus, motivation, and overall quality of life with consistent treatments.
  
• Reduced Need for Medication
  Many patients are able to lower doses or discontinue other psychiatric medications under medical supervision.
  
• Safe and Monitored Approach
  Ketamine is administered in a medically controlled setting by licensed professionals who monitor safety, comfort, and efficacy.

After your initial 6-session series, our team will work with you to determine the best maintenance plan, which may include:

• Booster infusions every 4–6 weeks
  
• Adjunctive therapies (e.g., talk therapy, IV nutrition, mindfulness)
  
• Ongoing evaluations to track and support your progress

Aan Het Rot, M., Zarate, C. A., Charney, D. S., & Mathew, S. J. (2012). Biological Psychiatry, 72(7), 537–547. https://doi.org/10.1016/j.biopsych.2012.05.003

Murrough, J. W., Perez, A. M., Pillemer, S., Stern, J., Parides, M. K., Aan Het Rot, M., ... & Iosifescu, D. V. (2013). Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biological Psychiatry, 74(4), 250–256. https://doi.org/10.1016/j.biopsych.2012.06.022

Shiroma, P. R., Thuras, P., Johns, B., Luckenbaugh, D., & Wels, J. (2014). Augmentation of response and remission to serial intravenous subanesthetic ketamine in treatment-resistant depression. Journal of Affective Disorders, 155, 123–129. https://doi.org/10.1016/j.jad.2013.10.036

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